Citrus aurantium (bitter orange) is one of the most common traditional Chinese medicines. Olea oleuropaea (olive) leaf was used in ancient Egypt and Greece for its positive effects on blood pressure and immunity. CitrOlive™ combines these two botanicals to provide synergistic activity to support health and wellness.
CitrOlive™ is the product of extensive research into the major phytochemicals, polyphenols and flavonoids that characterize citrus and olive and provide strong antioxidant activity. CitrOlive™ delivers phytonutrients common to the Mediterranean diet in concentrated form. The broad range of benefits include immune-related and antioxidant effects and cardiovascular endothelium protection1.
In a preclinical study of short (1 day) and long-term (60 days) duration, CitrOlive™ was found to have beneficial effect on lipid metabolism. In participants on a high fat diet, the CitrOlive group demonstrated a significant reduction in postprandial triglycerides and liver inflammatory markers2.
In a clinical study, consumption of a 500mg of Citrolive™ capsules twice a day, for 90 days in previously untreated subjects with moderate risk of atherosclerosis was associated with a statistically significant reduction in oxidized LDL-C (-33%) and LDL-oxidase/LDL-C ratio as compared to controls who took a placebo. Paraoxonase-1, a marker for HDL, levels also increased which is associated with lower risk for cardiovascular disease3.
In an ex vivo study using aorta rings from spontaneously hypertensive rats, Citrolive™ demonstrated an endothelium-dependent vascular relaxing effect. Endothelial nitrous oxide (NO) and prostacyclin release are the likely drivers of the vascular relaxing effect1.
1. López-Carreras et al., Food Research International 2015
2. Merola et al., Nutrients 2017
3. Victoria-Montesinos et al., Antioxidants 2021, 10