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Skin aging is influenced by internal and external factors, such as changes in estrogen production and exposure to free radicals. During and after menopause, falling estrogen levels cause a decrease in general skin tone, wrinkles and sagging. Aging skin tissue typically stiffens and loses elasticity. The responsible process for this is called collagen protein glycation and occurs because glucose forms cross-links between collagen molecules, making collagen protein less flexible.

SoyLife was incorporated in a standard cream (with a final concentration of 0.18% isoflavones) and tested on healthy menopausal women. The study was performed on two groups of each 10 healthy menopausal women (45-65 yrs). One group used the SoyLife cream and the second a placebo cream. The subjects used the cream twice a day for 8 weeks. On day 0, day 28 and day 56 silicone prints of the crow’s feet were taken from each subject. The anti-wrinkle effect was measured using Skin Analyzer

It has been shown that SoyLife isoflavones have a possible anti-aging effect on skin tissue by reducing the glycation of collagen protein. As a result, it helps maintain the skin’s elasticity, both applied topically and taken orally. An in vitro study measuring Advance Glycosylation Endproducts (AGE) showed that SoyLife EXTRA (standardized on 10% isoflavones) may have an anti-aging effect on skin tissue by reducing the glycation of collagen protein. As a result, the process of elasticity loss in the skin may be slowed down.

After day 28 the SoyLife cream significantly reduced the number of deep wrinkles by 24%. This effect was maintained at 22% after 56 days. The placebo group did not show a significant effect.

Cutaneous microcirculation (skin blood flow) was tested in 10 healthy menopausal women who used the standard cream with SoyLife EXTRA, twice a day for eight weeks. On day 0 and on day 56 cutaneous microcirculation was measured by a Laser Doppler on the cheeks of the subject. Results show that after using the SoyLife® cream, the skin blood flow decreased significantly. After 8 weeks, a decrease of 36.5% was observed. SoyLife EXTRA can therefore be used in creams to calm skin redness and sensitive skin as well as to improve skin radiance.

Sensory evaluation was done with a subjective questionnaire regarding tolerance, organoleptic parameters and product efficacy. After 56 days of twice daily application the results show that SoyLife cream was well accepted. Particularly good tolerance, high efficacy and very pleasant sensations were reported


  • Dermscan 2000Protective effects of SoyLife® against protein glycation, unpublished results
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