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SKIN HEALTH SCIENCE

Years of work on probiotics and skin health, and the screening of different probiotic strains led to the selection of a specific strain, Bifidobacterium animalis subsp. lactis Bl-04®. Multiple in vitro studies with human dermal fibroblast, one human clinical study, and a consumer perception study all support the benefits of Bl-04® on skin.

Probiotic Bl-04® effects based on skin beauty in vitro results with human dermal
fibroblasts & human clinical study

SKIN WRINKLE FORMATION BI-04 shows collagen metabolism balance in vitro PHOTOAGING BI-04 shows improvement of skin cell viability in stress in vitro BI-04 shows increase of pro-collagen synthesis in vitro BI-04 shows effect on skin wrinkles in human clinical study at 4 weeks BI-04 shows inhibition of inflammation-induced matrix degradation in vitro Oxidative stress (ROS) Activation of matrix metalloproteinases Collagen degradation Pro-inflammatory cytokines Decrease of collagen production image
SKIN WRINKLE FORMATION PHOTOAGING Oxidative stress(ROS) Activation of matrix metalloproteinases Collagen degradation Pro-inflammatory cytokines Decrease of collagen production BI-04 shows inflammation-induced matrix degradation in vitro BI-04 shows pro-collagen in vitro BI-04 shows improvement of skin cell viability in stress in vitro BI-04 shows metabolism balance in vitro BI-04 shows effect on skin wrinkles in human clinical study at 4 weeks image

Illustration: Ilmari Hakala

Phosphatidylserine (PS) effects on dermal fibroblasts in vitro &
in human clinical study

SKIN WRINKLE FORMATIONPS shows inhibition of UV-induced collagen degradation in vitroPHOTOAGINGCHRONOLOGICAL AGINGSoluble keratin proteins increase the ability of skin cells to produce collagen IV in vitroInflammation and oxidative stressActivation of matrix metalloproteinasesCollagen degradationSKIN DEHYDRATIONAND SENSITIVITYPS shows inhibition of wrinkle formation in human clinical trailPS is the major component in cell membranes. PS shows improvement in skin moisture in human clinical trailSKIN DEHYDRATIONAND SENSITIVITY image