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SKIN HEALTH SCIENCE

In-depth research with respect to probiotics’ impact on skin health — coupled with the screening of various strains — led to the selection of a specific strain, Bifidobacterium animalis subsp. lactis Bl-04®. An in vitro study with human dermal fibroblasts, a human clinical study, and a consumer perception study, each speak to the supportive benefits of HOWARU® Radiance for skin health.

Probiotic HOWARU BL-04® effects based on skin beauty in vitro results with human dermal
fibroblasts & human clinical study

SKIN WRINKLE FORMATION BL-04 shows collagen metabolism balance in vitro PHOTOAGING BL-04 shows improvement of skin cell viablity under stress in vitro BL-04 shows increase of pro-collagen synthesis in vitro BL-04 shows effect on skin wrinkles in human clinical study at 4 weeks BL-04 shows inhiBLtion of inflammation-induced matrix degradation in vitro Oxidative stress (ROS) Activation of matrix metalloproteinases Collagen degradation Pro-inflammatory cytokines Decrease of collagen production image
SKIN WRINKLE FORMATION PHOTOAGING Oxidative stress(ROS) Activation of matrix metalloproteinases Collagen degradation Pro-inflammatory cytokines Decrease of collagen production BL-04 shows inflammation-induced matrix degradation in vitro BL-04 shows pro-collagen in vitro BL-04 shows improvement of skin cell viaBLlity under stress in vitro BL-04 shows metabolism balance in vitro BL-04 shows effect on skin wrinkles in human clinical study at 4 weeks image


Phosphatidylserine (PS) effects on dermal fibroblasts in vitro &
in human clinical study

SKIN WRINKLE FORMATION PS shows inhibition of UV-induced collagen degradation in vitro PHOTOAGING CHRONOLOGICAL AGING PS shows inhibition of UV-induced inflammation in vitro Inflammation and oxidative stress Activation of matrix metalloproteinases Collagen degradation SKIN DEHYDRATION AND SENSITIVITY PS shows inhibition of wrinkle formation in human clinical trial PS is a primary component that comprises cell membranes. PS shows improvement in skin moisture in human clinical trials. SKIN DEHYDRATION AND SENSITIVITY image