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SKIN HEALTH SCIENCE

In-depth research with respect to probiotics’ impact on skin health — coupled with the screening of various strains — led to the selection of a specific strain, Bifidobacterium animalis subsp. lactis Bl-04®. An in vitro study with human dermal fibroblasts, a human clinical study, and a consumer perception study, each speak to the supportive benefits of HOWARU® Radiance for skin health.

Probiotic HOWARU BL-04® effects based on skin beauty in vitro results with human dermal
fibroblasts & human clinical study

SKIN WRINKLE FORMATION BL-04 shows collagen metabolism balance in vitro PHOTOAGING BL-04 shows improvement of skin cell viablity under stress in vitro BL-04 shows increase of pro-collagen synthesis in vitro BL-04 shows effect on skin wrinkles in human clinical study at 4 weeks BL-04 shows inhiBLtion of inflammation-induced matrix degradation in vitro Oxidative stress (ROS) Activation of matrix metalloproteinases Collagen degradation Pro-inflammatory cytokines Decrease of collagen production image
SKIN WRINKLE FORMATION PHOTOAGING Oxidative stress(ROS) Activation of matrix metalloproteinases Collagen degradation Pro-inflammatory cytokines Decrease of collagen production BL-04 shows inflammation-induced matrix degradation in vitro BL-04 shows pro-collagen in vitro BL-04 shows improvement of skin cell viaBLlity under stress in vitro BL-04 shows metabolism balance in vitro BL-04 shows effect on skin wrinkles in human clinical study at 4 weeks image


Phosphatidylserine (PS) effects on dermal fibroblasts in vitro &
in human clinical study

SKIN WRINKLE FORMATION PS shows inhibition of UV-induced collagen degradation in vitro PHOTOAGING CHRONOLOGICAL AGING PS shows inhibition of UV-induced inflammation in vitro Inflammation and oxidative stress Activation of matrix metalloproteinases Collagen degradation SKIN DEHYDRATION AND SENSITIVITY PS shows inhibition of wrinkle formation in human clinical trial PS is a primary component that comprises cell membranes. PS shows improvement in skin moisture in human clinical trials. SKIN DEHYDRATION AND SENSITIVITY image
SKIN WRINKLE FORMATION PS shows inhibition of UV-induced collagen degradation in vitro PHOTOAGING CHRONOLOGICAL AGING Solublekeratin proteins increase the ability of skin cells to produce collagen IV in vitro Inflammation and oxidative stress Activation of matrix metaloproteinases Collagen degradation SKIN DEHYDRATION AND SENSITIVITY PS shows inhibition of wrinkle formation in human clinical Trial PS is the major component in cell membranes. PS shows improvement in skin SKIN DEHYDRATION AND SENSITIVITY CHRONOLOGICAL AGING SKIN DEHYDRATION AND SENSITIVITY PS is the major component in cell membranes. PS shows improvement in skin moisture in human clinical trial image


Keratin effects based on skin beauty in vitro, ex vivo results & human
clinical study

PHOTOAGING & POLLUTANTS Oxidative stress Soluble keratin proteins increase the ability of skin cells to produce collagen in vitro KeraGEN-IV® improves skin elasticity in human clinical study Decrease of collagen IV and VII. Collagen is essential in demo-epithelial junction and anchoring the bulb of the hair follicle Impairment of scalp's ability to support healthy hairgrowth Soluble keratin can provide protection against oxidative stress KeraGEN-IV® shows reduced hair loss in a hair pull test in human clinical study Degradation of demo-epidermal junction SKIN WRINKLE FORMATION HAIR LOSS image
Degradation of demo-epidermal junction SKIN WRINKLE FORMATION HAIR LOSS PHOTOAGING & POLLUTANTS OXidative stress Decrease of collagen IV and VII. Collagen is essential in demo-epithelial junction and anchoring the bulb of the hair follicle KeraGEN-IV® improves skin elasticity in human clinical study Soluble keratin proteins increase the ability of skin cells to produce collagen in vitro KeraGEN-IV® shows reduced hair loss in a hair pull test in human clinical study Soluble keratin can provide protection against oxidative stress Impairment of scalp’s ability of support health hair growth image

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