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More than 35 proprietary scientific studies have confirmed the safety and efficacy of SoyLife in alleviating menopausal symptoms and supporting bone and cardiovascular health, making it one of the most researched isoflavone ingredients. SoyLife has also shown to be effective for gut health and skin care.

The efficacy and safety profile of SoyLife have been extensively investigated in multiple scientific studies, ranging from in-vitro experiments to clinical trials. SoyLife is protected by a large portfolio of intellectual property, including several patents. IFF Health continues to fund research to further support the clinical efficacy and safety of SoyLife.

Isoflavones bind preferentially to the estrogen receptor
and cause a weak estrogenic or anti-estrogenic effect

Soy isoflavones have a weak estrogenic hormone-like activity. Estrogens are signaling molecules that exert their effects by binding to estrogen receptors in cells. Soy isoflavones have a structural similarity to 17-β-estradiol and bind the same receptors. The estrogen-receptor complex interacts with DNA to modify the expression of estrogen-responsive genes.

Estrogen receptors are found in numerous tissues including reproductive tissues, bone, liver, heart, and brain. Soy isoflavones preferentially bind to estrogen receptor-β, mimicking the effects of estrogen in some tissues and blocking the effects of estrogen in others.

This estrogenic effect is dependent on the tissue. Anti-estrogenic effects of phytoestrogens in reproductive tissue could help reduce the risk of hormone-associated cancers (breast, uterine, and prostate), while estrogenic effects in other tissues could help maintain bone mineral density and improve blood lipid profiles. Soy isoflavones may alter the biological activity of endogenous estrogens and androgens by inhibiting the synthesis and activity of enzymes involved in estrogen metabolism.

Soy isoflavones and their metabolites also have biological activities that are unrelated to their interactions with estrogen receptors. For example, soy isoflavones can inhibit tyrosine kinases, enzymes that stimulate cell proliferation and thus are potential molecules of interest in anti-cancer research.

Health benefits

Women during and after menopause may find that isoflavones relieve their hot flashes and support overall well-being. Clinical studies show positive effects
of SoyLife to support bone and cardiovascular health in women during menopause.

  •  

    WOMEN’S HEALTH AND MENOPAUSE

    During menopause women produce less estrogen, which can lead to symptoms including hot-flashes, insomnia and mood swings and affects breast and bone health.

    Read the science
  •  

    BONE HEALTH

    Estrogen plays an important role in bone metabolism, especially influencing the mechanisms related to calcium resorption.

    Read the science
  •  

    SKIN CARE

    During and after menopause, falling estrogen levels cause changes in general skin tone, wrinkles, and sagging. This is related to collagen protein glycation.

    Read the science
  •  

    HEART HEALTH

    When estrogen production drops during menopause, it results in a higher risk of hypercholesterolemia and hypertension in postmenopausal women.

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  •  

    MEMORY AND COGNITIVE FUNCTION

    Evidence from studies using SoyLife show that men who supplement their diets with isoflavones may significantly improve their spatial working memory.

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  •  

    GUT HEALTH

    Other soy constituents including dietary fiber, oligosaccharides, proteins, trace minerals and vitamins can influence wellbeing and the efficacy of isoflavones.

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Safety of soy supplementation

In women:

In Asia, the region where soy consumption is the highest, breast cancer incidence happens to be relatively lower in comparison with Western countries. Therefore soy has come to the attention of researchers as an ingredient that may help prevent the development of breast cancer. Because soy isoflavones are structurally similar to estrogen, they can weakly bind to estrogen receptors when the local estrogen concentration is low. As a result, many studies have demonstrated the breast cancer prevention effects of soy isoflavones. However, the potential estrogenic effect of soy isoflavones raised the concern whether soy isoflavones were safe to be consumed by breast cancer patients or women at high risk for breast cancer.

The Osteoporosis Prevention Using Soy (OPUS) study examined the correlation between different doses of an isoflavone supplement and mammographic density in a 2-year long clinical trial designed to document the safety, efficacy and optimal dosage of soy isoflavones to prevent bone loss after menopause.
Taking an isoflavone supplement did not influence mammographic breast density in postmenopausal women. Stratification by age and BMI also did not indicate an effect of the treatment for any subgroup of women.
These results show that a long-term intake of soy germ isoflavones in high concentrations do not have a negative influence on breast health.

In men:

Soy isoflavones have been consumed by humans as part of soy-based diets for many years without any evidence of adverse effects.
Claims that soy and isoflavone consumption can have adverse effects on male reproductive function, including feminization, are primarily based on animal studies. Exposure to isoflavones (even levels above typical Asian dietary intakes) has not been shown to affect either the concentrations of estrogen and testosterone, or male fertility. Systematic reviews of the scientific literature found no basis for concern for the use of soy isoflavones by men. The efficacy and safety of SoyLife in particular have been extensively scrutinized in multiple scientific studies, ranging from in-vitro experiments to clinical trials.

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